Within our cellular types, RAS as well as the IGF-1R were both internalized and categorized into early endosomes, while indicated simply by colocalization with RAB5 (Figure4Aand4C), but while NIVEL followed CD99 and colocalized with LAMP-1 in late endosomes/lysosome-like vacuoles (Figure4B), the IGF-1R did not (Figure4D; Mander’s overlap < 0

Within our cellular types, RAS as well as the IGF-1R were both internalized and categorized into early endosomes, while indicated…