The HHV6 paradox: ubiquitous commensal or insidious pathogen? a two-step in situ PCR approach

The HHV6 paradox: ubiquitous commensal or insidious pathogen? a two-step in situ PCR approach. al. Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study. 2001;248(2):131-138 [PubMed] [Google Scholar] 6. Edwards S, Zvartau M, Clarke H, Irving W, Blumhardt LD. Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis. 1998;64(6):736-741 [PMC free article] [PubMed] [Google Scholar] 7. Panitch HS. Influence of infection on exacerbations of multiple sclerosis. 1994;36(suppl):S25-S28 [PMC free article] [PubMed] [Google Scholar] 8. Sibley WA, Bamford CR, Clark K. Clinical viral infections and multiple sclerosis. 1999;74(2):163-170 [PubMed] [Google Scholar] 10. Meinl E. Concepts of viral pathogenesis of multiple sclerosis. 1999;12(3):303-307 [PubMed] [Google Scholar] 11. Dimethyl 4-hydroxyisophthalate Moore FG, Wolfson C. Human herpes virus 6 and multiple sclerosis. 1979;121(9):1193-1254 [PMC free article] [PubMed] [Google Scholar] 13. Kuusisto H, Hyoty H, Dimethyl 4-hydroxyisophthalate Kares S, Kinnunen E, Elovaara I. Human Rabbit polyclonal to SUMO3 herpes virus 6 and multiple sclerosis: a Finnish twin study. 2008;14(1):54-58 [PubMed] [Google Scholar] 14. Virtanen JO, Farkkila M, Multanen J, et al. Evidence for human herpesvirus 6 variant A antibodies in multiple sclerosis: diagnostic and therapeutic implications. 2007;13(4):347-352 [PubMed] [Google Scholar] 15. Derfuss T, Hohlfeld R, Meinl E. Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspcific B-cell response. 2005;252(8):968-971 [PubMed] [Google Scholar] 16. Villoslada P, Juste C, Tintore M, et al. The immune response against herpesvirus is more prominent in the early stages of MS. 2003;69(1):111-117 [PubMed] [Google Scholar] 18. Gutierrez J, Vergara MJ, Guerrero M, et al. Multiple sclerosis and human herpesvirus 6. 2002;66(3):394-399 [PubMed] [Google Scholar] 20. Cirone M, Cuomo L, Zompetta C, et al. Human herpesvirus 6 and multiple sclerosis: a study of T cell cross-reactivity to viral and myelin basic protein antigens. 2002;68(2):268-272 [PMC free article] [PubMed] [Google Scholar] 21. Enbom M, Linde A, Evengard B. No evidence of active infection with human herpesvirus 6 (HHV-6) or HHV-8 in chronic fatigue syndrome [letter]. 2000;38(6):2457 [PMC free article] [PubMed] [Google Scholar] 22. Ablashi DV, Eastman HB, Owen CB, et al. Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients. 2000;16(3):179-191 [PubMed] [Google Scholar] 23. Taus C, Pucci E, Cartechini E, et al. Absence of HHV-6 and HHV-7 in cerebrospinal fluid Dimethyl 4-hydroxyisophthalate in relapsing-remitting multiple sclerosis. 2000;101(4):224-228 [PubMed] [Google Scholar] 24. Ongradi J, Rajda C, Marodi CL, Csiszar A, Vecsei L. A pilot study on the antibodies to HHV-6 variants and HHV-7 in CSF of MS patients. 1999;5(5):529-532 [PubMed] [Google Scholar] 25. Ablashi DV, Lapps W, Kaplan M, Whitman Dimethyl 4-hydroxyisophthalate JE, Richert JR, Pearson GR. Human herpesvirus-6 (HHV-6) infection in multiple sclerosis: a preliminary report. 1998;4(6):490-496 [PubMed] [Google Scholar] 26. Nielsen L, Larsen AM, Munk M, Vestergaard BF. Human herpesvirus-6 immunoglobulin G antibodies in patients with multiple sclerosis. 1997;169:76-78 [PubMed] [Google Scholar] 27. Soldan SS, Berti R, Salem N, et al. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. 1997;3(12):1394-1397 [PubMed] [Google Scholar] 28. Liedtke W, Malessa R, Faustmann PM, Eis-Hubinger AM. Human herpesvirus 6 polymerase chain reaction findings in human immunodeficiency virus associated neurological disease and multiple sclerosis. 1995;1(3-4):253-258 [PubMed] [Google Scholar] 29. Wilborn F, Schmidt CA, Brinkmann V, Jendroska K, Oettle H, Siegert W. A potential role for human herpesvirus type 6 in nervous system disease. 1994;49(1-2):213-214 [PubMed] [Google Scholar] 30. Sola P, Merelli E, Marasca R, et al. Human herpesvirus 6 and multiple sclerosis: survey of anti-HHV-6 antibodies by immunofluorescence analysis and of viral sequences by polymerase chain reaction. 1999;6(4):545-549 [PMC free article] [PubMed] [Google Scholar] 32. Friedman JE, Lyons MJ, Cu G, et al. The association of the human herpesvirus-6 and MS. 1999;5(5):355-362 [PubMed] [Google Scholar] 33. Lunde MN, Gelderman AH, Hayes SL, Vogel CL. Serologic diagnosis of active toxoplasmosis complicating malignant diseases: usefulness of IgM antibodies and gel-diffusion. 1995;172(5):1364-1367 [PubMed] [Google Scholar] 35. Wilborn F, Schmidt CA, Zimmermann R, Brinkmann V, Neipel F, Siegert W..